full transcript

From the Ted Talk by Li-Huei Tsai: Could we treat Alzheimer's with light and sound?

Unscramble the Blue Letters

So the light and snuod slmttiuoian approach seems cool and flashy. Literally. But what amazes the most is that it produced profound and widespread benefits in mice engineered to model this dsesiae. Mice exposed to gamma lhgit and sound stimulation had major reductions in protein build-ups, amyloid plaques and tau tangles that are hallmarks of Alzheimer's progression. The stimulation preserved more of the connections or synapses that bind nerve cells into cturciis. More cells survived, so the brain dayeecd less. The brain naturally has open spaces known as ventricles. And in the brain of mice left untreated, these ventricles became very big. But in the brian of mice exposed to gamma-wave stimulation, these ventricles are closer to the size of healthy mice. And consistent with all of these phcyisal differences, Alzheimer's mice exposed to light and sound stimulation show better performance on lnairneg and memroy tests than uereanttd mice did.

Open Cloze

So the light and _____ ___________ approach seems cool and flashy. Literally. But what amazes the most is that it produced profound and widespread benefits in mice engineered to model this _______. Mice exposed to gamma _____ and sound stimulation had major reductions in protein build-ups, amyloid plaques and tau tangles that are hallmarks of Alzheimer's progression. The stimulation preserved more of the connections or synapses that bind nerve cells into ________. More cells survived, so the brain _______ less. The brain naturally has open spaces known as ventricles. And in the brain of mice left untreated, these ventricles became very big. But in the _____ of mice exposed to gamma-wave stimulation, these ventricles are closer to the size of healthy mice. And consistent with all of these ________ differences, Alzheimer's mice exposed to light and sound stimulation show better performance on ________ and ______ tests than _________ mice did.

Solution

  1. circuits
  2. disease
  3. brain
  4. learning
  5. decayed
  6. light
  7. stimulation
  8. untreated
  9. physical
  10. sound
  11. memory

Original Text

So the light and sound stimulation approach seems cool and flashy. Literally. But what amazes the most is that it produced profound and widespread benefits in mice engineered to model this disease. Mice exposed to gamma light and sound stimulation had major reductions in protein build-ups, amyloid plaques and tau tangles that are hallmarks of Alzheimer's progression. The stimulation preserved more of the connections or synapses that bind nerve cells into circuits. More cells survived, so the brain decayed less. The brain naturally has open spaces known as ventricles. And in the brain of mice left untreated, these ventricles became very big. But in the brain of mice exposed to gamma-wave stimulation, these ventricles are closer to the size of healthy mice. And consistent with all of these physical differences, Alzheimer's mice exposed to light and sound stimulation show better performance on learning and memory tests than untreated mice did.

Frequently Occurring Word Combinations

ngrams of length 2

collocation frequency
gamma waves 9
sound stimulation 6
gamma light 4
mice exposed 3
gamma wave 3
wave stimulation 3
nerve cells 2
showing mice 2
stimulation approach 2
approach appears 2
start early 2

ngrams of length 3

collocation frequency
gamma wave stimulation 3
sound stimulation approach 2

Important Words

  1. amazes
  2. amyloid
  3. approach
  4. benefits
  5. big
  6. bind
  7. brain
  8. cells
  9. circuits
  10. closer
  11. connections
  12. consistent
  13. cool
  14. decayed
  15. differences
  16. disease
  17. engineered
  18. exposed
  19. flashy
  20. gamma
  21. hallmarks
  22. healthy
  23. learning
  24. left
  25. light
  26. literally
  27. major
  28. memory
  29. mice
  30. model
  31. naturally
  32. nerve
  33. open
  34. performance
  35. physical
  36. plaques
  37. preserved
  38. produced
  39. profound
  40. progression
  41. protein
  42. reductions
  43. show
  44. size
  45. sound
  46. spaces
  47. stimulation
  48. survived
  49. synapses
  50. tangles
  51. tau
  52. tests
  53. untreated
  54. ventricles
  55. widespread